Melanotan I 10mg Pen

Melanotan I 10 mg Pen

Product Description

Melanotan I, also known as Afamelanotide, MT-I, or NDP-MSH, is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) developed for research into melanocortin signalling, pigmentation biology, melanogenesis, and photoprotection.

Its primary research target is the melanocortin-1 receptor (MC1R) expressed on melanocytes. Activation of MC1R stimulates intracellular signalling involved in the production of eumelanin, the darker melanin pigment associated with skin pigmentation and natural photoprotective responses.

Compared with broader melanocortin agonists, Melanotan I is described in the supplied material as having greater selectivity toward pigmentation-related MC1R pathways. Pasted text

The Atlas Longevity Melanotan I pen contains 10 mg in a 3 mL pre-mixed cartridge with 300 total units/clicks.

Afamelanotide has been clinically studied and has regulatory approval in certain jurisdictions for specific photoprotection indications. However, that regulatory status applies to specific approved formulations and indications and should not be interpreted as approval of the Atlas Longevity pre-mixed pen or of Melanotan I for cosmetic tanning.

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Clinical / Research Status

Melanotan I / Afamelanotide has a more developed human evidence base than many experimental peptides.

The supplied material identifies:

The source specifically notes clinical evaluation and approval for certain photoprotection indications. Pasted text

This distinction is important:

Approval of an Afamelanotide medicinal product does not automatically mean that every Melanotan I formulation, injection pen, concentration, or use is approved.

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Evidence Type

The supplied material includes research involving:

• erythropoietic protoporphyria clinical trials;
• healthy human pigmentation studies;
• vitiligo combination studies;
• melanocyte cell cultures;
• UV-exposure animal models;
• photosensitivity research;
• pharmacokinetic studies involving an implant formulation. Pasted text

Evidence should always be interpreted according to the specific formulation and indication studied.

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Mechanism of Action

Melanotan I acts primarily as an agonist of the melanocortin-1 receptor (MC1R).

MC1R is expressed on melanocytes, the cells responsible for producing melanin.

When MC1R is activated, intracellular signalling involving cyclic AMP (cAMP) increases. This signalling can influence:

• MITF-related transcription;
• tyrosinase activity;
• melanogenesis;
• eumelanin production;
• pigmentation responses.

The supplied material describes Melanotan I as a more stable analogue of endogenous α-MSH with greater resistance to enzymatic breakdown and more sustained receptor engagement. Pasted text

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Potential Benefits / Research Areas

MC1R Signalling Research

Melanotan I is primarily studied for selective activation of MC1R receptors.

These receptors regulate melanocyte signalling pathways involved in skin pigmentation and eumelanin synthesis.

Because Melanotan I is described as relatively selective for MC1R, it is particularly relevant to focused research involving pigmentation rather than broader melanocortin-system activity. Pasted text

Eumelanin Production Research

Activation of MC1R can increase cAMP signalling and stimulate pathways involved in melanin production.

The supplied material specifically describes:

• increased MITF signalling;
• increased tyrosinase-related activity;
• increased eumelanin production. Pasted text

These mechanisms form the main scientific basis for Melanotan I pigmentation research.

Photoprotection Research

Melanin absorbs and dissipates part of the energy associated with ultraviolet exposure.

For this reason, increased eumelanin production has been investigated in research examining photoprotection and UV-response biology.

The supplied source describes human research involving EPP and experimental models examining UV-associated skin responses. Pasted text

This should not be interpreted as meaning Melanotan I replaces sunscreen, protective clothing, or other established UV-protection measures.

Stability Compared With Natural α-MSH

Natural α-MSH is rapidly degraded.

Melanotan I contains structural modifications intended to improve peptide stability and prolong interaction with melanocortin receptors.

This makes it more suitable for controlled research than native α-MSH in certain experimental settings. Pasted text

Dermatological Research

Melanotan I / Afamelanotide has been investigated in several dermatological research areas, including:

• photosensitivity;
• pigmentation biology;
• EPP;
• vitiligo-related repigmentation;
• UV-response pathways.

The supplied material describes controlled human research in some of these areas. Pasted text

Results from specialist dermatological indications should not automatically be converted into cosmetic tanning claims.

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Research Data

The research includes strong human evidence for specific medical and photobiological contexts, but findings from approved implant formulations should not automatically be applied to an Atlas Longevity pre-mixed pen. Pasted text

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Potential Stack / Combination Research

The supplied source discusses experimental combination concepts involving Melanotan I with:

• GHK-Cu;
• Glutathione;
• BPC-157;
• Epitalon. Pasted text

The proposed research rationale involves pigmentation, extracellular-matrix biology, antioxidant pathways, tissue repair, and ageing-related skin research.

However, the supplied information does not establish validated human safety, compatibility, efficacy, or dosing for these combinations.

They should therefore be regarded as experimental research concepts rather than recommended stacks.

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Atlas Longevity Melanotan I Pen Dosage / Click Chart

The Atlas Longevity Melanotan I pen contains:

10 mg Melanotan I

3 mL cartridge volume

300 total clicks

1 click = 0.01 mL

Maximum selectable dial amount = 60 clicks

Pen Specification

Concentration Calculation

10 mg ÷ 3 mL = 3.3333 mg/mL

Rounded:

≈3.333 mg/mL

Amount Per Click

10 mg ÷ 300 clicks = 0.033333 mg per click

Therefore:

1 click ≈0.0333 mg

or:

≈33.3 mcg Melanotan I

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Melanotan I Click Conversion Chart

Useful Conversions

• 15 clicks = 0.50 mg
• 30 clicks = 1 mg
• 45 clicks = 1.50 mg
• 60 clicks = 2 mg

The maximum selectable amount in one dial operation is:

60 clicks = 0.60 mL = 2 mg Melanotan I

This is a mathematical concentration conversion and not a dosing recommendation.

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Protocol / Dosage Information

The supplied source describes experimental quantities ranging from approximately 0.25 mg to 2 mg. Pasted text

Its original click calculations were based on a different 10 mg / 2 mL formulation, so those click values cannot be copied into the Atlas Longevity pen.

Using the Atlas 10 mg / 3 mL / 300-click formulation:

*A calculated value of 7.5 clicks cannot be selected exactly using whole pen units.

The source also provides schedules involving daily or repeated administration. These should not be converted into self-administration instructions for the Atlas product.

The table above simply translates source-referenced quantities into Atlas concentration mathematics.

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Possible Side Effects

The supplied material describes several adverse effects observed in Melanotan I / Afamelanotide research.

These include:

• localized injection-site redness or irritation;
• nausea;
• temporary gastrointestinal discomfort;
• headache;
• mild fatigue;
• facial flushing or warmth;
• darkening of existing freckles;
• darkening of existing nevi or moles. Pasted text

Pigmentation Changes

Because Melanotan I directly stimulates melanogenesis, pigmentation changes are expected to be a major biological effect.

This can include darkening of:

• skin;
• freckles;
• existing pigmented lesions;
• nevi.

Changes in existing moles or newly changing pigmented lesions should not be dismissed simply as an expected cosmetic effect.

Long-Term Safety

The supplied material describes a generally favorable safety profile within specific clinical contexts.

However, the evidence does not establish complete safety for:

• cosmetic tanning use;
• different injectable formulations;
• prolonged unsupervised exposure;
• repeated high exposure;
• combination protocols;
• individuals with dermatological risk factors.

Regulatory experience with an approved Afamelanotide product should not automatically be used to claim that every Melanotan I product or route has the same safety profile.

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Product Attributes

These specifications are reported in the supplied reference material.

Included in the Box

Each Atlas Longevity product is carefully packed to support secure storage, clean handling, and convenient research use. Inside the package, you’ll find the essential items needed for organized laboratory handling:

• 1× Ready-to-Use Injection Pen
• 10× Ultra-Fine Needles (33G, 4 mm)
• 10× Alcohol Prep Pads
• Protective Foam Insert to help keep the pen secure during transport
• Quick-Reference Instruction Panel inside the packaging
• Tamper-Evident Security Seal for added package protection

Each component is arranged in a clean, protective presentation designed to keep the product secure and easy to access.

Storage

Storage conditions should follow the instructions supplied specifically with the Atlas Longevity Melanotan I formulation.

The reference product provides refrigeration and stability specifications for its own finished formulation. Those conditions should not automatically be transferred to Atlas Longevity without formulation-specific stability evidence.

Follow the temperature requirements, light-protection guidance, handling instructions, and shelf-life information printed on the Atlas Longevity product label or accompanying documentation.

The source also lists a proprietary approved product name as a synonym. That branding should not be used as Atlas Longevity product terminology.

 

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Frequently Asked Questions

What is Melanotan I?

Melanotan I is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH).

It is primarily studied for its ability to activate MC1R receptors and influence eumelanin production and pigmentation. Pasted text

Is Melanotan I the same as Afamelanotide?

The supplied source identifies Afamelanotide as another name for Melanotan I.

However, approved Afamelanotide medicinal products may use specific formulations and delivery systems that are not equivalent to an Atlas Longevity pre-mixed pen.

How does Melanotan I work?

Melanotan I activates MC1R receptors on melanocytes.

This can stimulate cAMP-related signalling, increase tyrosinase-related activity, and promote eumelanin production. Pasted text

What is MC1R?

MC1R stands for melanocortin-1 receptor.

It is a receptor expressed primarily on melanocytes and plays a major role in regulating pigmentation and eumelanin production.

What is eumelanin?

Eumelanin is a darker form of melanin pigment.

It contributes to skin and hair pigmentation and has greater UV-absorbing capacity than some lighter melanin forms.

What is Melanotan I researched for?

The supplied material describes research involving:

• melanogenesis;
• pigmentation;
• MC1R signalling;
• photoprotection;
• EPP;
• vitiligo;
• UV-response biology;
• photosensitivity.

Evidence strength varies depending on the specific indication and formulation.

Has Melanotan I been studied in humans?

Yes.

The supplied material includes controlled human trials, observational studies, and regulatory research involving Afamelanotide. Pasted text

Is Afamelanotide approved?

The supplied source states that Afamelanotide has regulatory approval in certain jurisdictions for specific photoprotection indications. Pasted text

That approval applies to particular authorized medicinal products and should not be interpreted as approval of all Melanotan I products or uses.

Is Melanotan I approved for cosmetic tanning?

The supplied material does not establish approval of Melanotan I for cosmetic tanning.

Clinical research and regulatory approval for a specific medical photoprotection indication should not be generalized to cosmetic use.

How much Melanotan I is in each Atlas Longevity pen?

Each Atlas Longevity Melanotan I pen contains:

10 mg in 3 mL.

What is the concentration of the Melanotan I pen?

The concentration is:

10 mg ÷ 3 mL = approximately 3.333 mg/mL

How many clicks are in the pen?

Each Atlas Longevity pen contains:

300 total clicks / units

with:

1 click = 0.01 mL

How much Melanotan I is in one click?

Each click contains approximately:

0.0333 mg

or:

33.3 mcg Melanotan I

How many clicks equal 0.5 mg?

15 clicks = 0.50 mg.

How many clicks equal 1 mg?

30 clicks = 1 mg.

How many clicks equal 2 mg?

60 clicks = 2 mg.

These are concentration calculations rather than dosing recommendations.

What is the maximum selectable amount on the Melanotan I pen?

The maximum single dial selection is:

60 clicks

which equals:

0.60 mL

and:

2 mg Melanotan I

This describes pen mechanics rather than a recommended amount.

How long does a Melanotan I pen last?

The full cartridge contains:

300 clicks and 10 mg Melanotan I.

The number of administrations depends on the number of clicks selected each time.

For cartridge-capacity calculation only:

• 10 clicks at a time = 30 administrations
• 15 clicks at a time = 20 administrations
• 20 clicks at a time = 15 administrations
• 30 clicks at a time = 10 administrations
• 60 clicks at a time = 5 administrations

These examples describe cartridge capacity rather than a therapeutic or tanning protocol.

Does the medication disappear when the dial returns to zero?

No.

After administration, the dial returns to zero while unused formulation remains inside the cartridge.

The remaining Melanotan I stays in the pen until all 300 units have been used.

Can Melanotan I darken moles or freckles?

The supplied clinical material reports darkening of pre-existing nevi and freckles as a possible effect associated with increased melanogenesis. Pasted text

Any concerning change in a pigmented lesion should not simply be assumed to be harmless pigmentation.

Does Melanotan I protect against UV exposure?

Afamelanotide has been studied in specific photoprotection settings, particularly EPP.

However, this should not be interpreted as permission to increase UV exposure or as a replacement for established sun-protection measures.

Can Melanotan I be combined with GHK-Cu or Glutathione?

The supplied source discusses these as experimental research concepts. Pasted text

It does not establish validated human safety, efficacy, compatibility, or dosing for these combinations.

Is there an established dosage for the Atlas Melanotan I pen?

The source contains research quantities, but those were based on a different formulation.

There is no universal approved dosing standard established by the supplied material for the Atlas Longevity pre-mixed pen.

The Atlas click chart therefore represents concentration mathematics only.

How should the Atlas Longevity Melanotan I pen be stored?

Follow the storage instructions supplied with the actual Atlas Longevity formulation.

The competitor product’s refrigeration and stability specifications relate to its own finished product and should not automatically be applied to Atlas without product-specific stability evidence.